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However, the initially hypothesized mechanism was incorrect, as it was later discovered that the hormone achieved its effects only when its concentration exceeded basal physiologic levels and that it operated similarly to secretin
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Potentiation of the cAMP accumulation produced by GLP-1(9-36) in combination with various fixed concentrations of positive allosteric modulator using mutant GLP-1R transiently transfected into HEK293 cells
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